| Title | Novel substituted thiazolidinedione derivatives as anti-diabetic agents |
| Publication Type | Journal Article |
| Year of Publication | 2017 |
| Authors | Rekha, S., and S. Chandrashekhara |
| Journal | European Journal of Pharmaceutical and Medical Research |
| Volume | 4 |
| Pagination | 643-652 |
| Date Published | 2017 |
| Type of Article | Article |
| ISBN Number | ISSN 2394-3211 |
| Keywords | College of Pharmaceutical Sciences, Others |
| Abstract | A set of novel of 5-[4-(substituted) benzylidene] thiazolidinediones were synthesized and evaluated as potential anti-diabetic agents. Thiazolidinediones scaffold- based molecules were synthesized and validated on a mice hyperglycemia model caused by dexamethasone. As a result few derivatives showed anti-hyperglycemic activities against standard drug rosiglitazone. This research provides useful clues for further design and discovery of anti-diabetic agents. |
| DOI |
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